Autophagy inhibitor 3-methyladenine protects against endothelial cell barrier dysfunction in acute lung injury
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چکیده
منابع مشابه
p53 protects against LPS-induced lung endothelial barrier dysfunction.
New therapies toward heart and blood vessel disorders may emerge from the development of Hsp90 inhibitors. Several independent studies suggest potent anti-inflammatory activities of those agents in human tissues. The molecular mechanisms responsible for their protective effects in the vasculature remain unclear. The present study demonstrates that the transcription factor p53, an Hsp90 client p...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2018
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00555.2016